Apogee Behavioral Medicine | May 13, 2025

When Depression Doesn’t Lift Depression is one of the most common and debilitating mental health conditions, affecting how you feel, think, and function each day. For many, it’s manageable with time, support, and treatment. But for some, even after trying multiple antidepressants, the symptoms don’t go away. This is known as treatment-resistant depression (TRD), and it can leave individuals feeling hopeless, disconnected, and unsure of where to turn next. If this sounds familiar, you’re not alone—and more importantly, you’re not out of options. At Apogee Behavioral Medicine, we offer Spravato®, an FDA-approved nasal spray treatment that is changing lives for people who haven’t found relief through traditional antidepressants. What Is Spravato®? Spravato® (esketamine) is a prescription nasal spray developed for adults with treatment-resistant depression or major depressive disorder (MDD) with suicidal thoughts or actions. Unlike standard antidepressants that affect serotonin...