When Depression Doesn’t Lift: How Spravato® Offers a New Path to Healing

When Depression Doesn’t Lift

Depression is one of the most common and debilitating mental health conditions, affecting how you feel, think, and function each day. For many, it’s manageable with time, support, and treatment. But for some, even after trying multiple antidepressants, the symptoms don’t go away. This is known as treatment-resistant depression (TRD), and it can leave individuals feeling hopeless, disconnected, and unsure of where to turn next.

If this sounds familiar, you’re not alone—and more importantly, you’re not out of options. At Apogee Behavioral Medicine, we offer Spravato®, an FDA-approved nasal spray treatment that is changing lives for people who haven’t found relief through traditional antidepressants.

What Is Spravato®?

Spravato® (esketamine) is a prescription nasal spray developed for adults with treatment-resistant depression or major depressive disorder (MDD) with suicidal thoughts or actions. Unlike standard antidepressants that affect serotonin or dopamine, Spravato® targets the glutamate system—a different pathway in the brain associated with mood regulation and neural connectivity. This unique approach makes Spravato® especially effective for people who haven’t responded to other medications.

A Faster Way to Feel Better

One of the most groundbreaking aspects of Spravato® is how quickly it can work. While traditional antidepressants may take weeks to show results, many patients experience symptom relief within 24 hours of their first dose. Spravato® is not a standalone therapy—it’s used alongside an oral antidepressant to enhance its effects and create a more complete, personalized treatment plan.

The Spravato® Treatment Experience

Treatment with Spravato® happens in a certified medical office like Apogee Behavioral Medicine, where it can be safely administered and monitored. Here’s what to expect:

• Initial Phase: Two treatments per week for the first four weeks
• Maintenance Phase: Ongoing treatment once a week or every other week depending on progress
• Each session: Lasts about two hours to allow time for monitoring and recovery

Patients self-administer the nasal spray in a calming environment while being closely observed by a licensed provider.

Who Is Spravato® For?

You may be a candidate for Spravato® if:

• You’ve tried two or more antidepressants without relief
• You’ve been diagnosed with treatment-resistant depression
• You are experiencing suicidal thoughts linked to major depressive disorder
• You are under the care of a mental health provider

Spravato® provides a crucial new option when standard treatments haven’t been enough.

Real Results from Clinical Studies

In multiple clinical trials:

• Patients taking Spravato® with an oral antidepressant had significantly greater symptom improvement than those taking an oral antidepressant alone.
• Many participants noticed relief within just 24 hours.
• Long-term studies showed a lower risk of relapse when continuing Spravato® treatment compared to stopping after the initial phase.

This evidence makes Spravato® one of the most promising new treatments for individuals with persistent, life-disrupting depression.

Is Spravato® Safe?

Spravato® is administered through a FDA-regulated Risk Evaluation and Mitigation Strategy (REMS) program, ensuring safety throughout treatment. As with any medication, side effects can occur, including dizziness, nausea, dissociation, or increased blood pressure. That’s why treatment is provided only in a clinical setting like Apogee, where patients are closely monitored. Because of potential side effects, patients should not drive or operate machinery for the rest of the day after each session.

Why Choose Apogee Behavioral Medicine for Spravato® Treatment?

At Apogee Behavioral Medicine, we specialize in evidence-based treatments for depression, and we are proud to offer Spravato® at our clinics across North Carolina. We believe that healing from depression requires personalized, compassionate care, and that’s exactly what you’ll find here.

• Board-certified providers trained in Spravato® administration
• In-network with major insurance plans
• A focus on whole-person mental health and long-term progress
• Comfortable, modern treatment centers are designed with patient safety and well-being in mind

Take the First Step Toward Feeling Better

If depression has taken over your life and nothing else has worked, it may be time to consider Spravato®. This innovative treatment is helping thousands reclaim their lives, and it could be right for you, too.

Call (855) 409-9002 or schedule an appointment online to learn more about Spravato® treatment at Apogee Behavioral Medicine. Your path forward doesn’t have to feel hopeless. Relief is possible, and we’re here to help you find it.